Professor Tetyana Duka

Tetyana Duka

Title:
Assistant Research Professor of Anthropology
Faculty: Resource
Office:
No on-campus office
Email:
tduka@email.gwu.edu

Dr. Duka is a neuroscientist with a special interest in nervous system functioning at the molecular level.  She is affiliated with GW's Laboratory for Evolutionary Neuroanatomy.

Current Research

Dr. Duka's primary research interests are in neuroscience and the use of comparative-phylogenetic approach to develop a deeper understanding of the relationship between brain structure, function, and evolution. Also, to explore the overlap between molecular changes observed in disorders of human cognitive abilities and evolutionary changes observed on the human lineage, in order to understand regulatory mechanisms that may be therapeutically modulated in neurological and psychiatric illnesses.

However, her research interests also include:

  • the physiopathology of debilitating and dementing neurodegenerative diseases;
  • signal transduction pathways involved in neuropsychiatric disorders such schizophrenia and depression;
  • age-related differences in synaptic plasticity.

Ongoing Projects

  • Functional profiling of the of the primate synaptic [neuro]proteome
  • Exploring the metabolic and genotypic changes that accompany the evolution of encephalization across different mammalian groups
  • Examining the correlation between behavioral lateralization, gross anatomical asymmetries, and organization of synapses in the primary motor cortex of chimpanzees (Pan troglodytes)

Education

Ph.D. 2003 (Biochemistry), National Taras Shevchenko University (Ukraine)
M.Sc. 1995 (Biophysics and Biochemistry), Dnepropetrovsk National University (Ukraine)

 

To see Dr. Duka's complete CV, click here.

Publications

Selected Articles and Book Chapters

2014  Duka, T., Z. Collins, S. Anderson, M.A. Raghanti, J.J. Ely, P.R. Hof, D.E. Wildman, L.I. Grossman, and C.C. Sherwood. "Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution," Brain, Behavior and Evolution 83(3):216-30. doi: 10.1159/000358581.

2012  Sherwood, C.C., and T. Duka. "Now that we've got the map, where are we going? Moving from gene candidate lists to function in studies of brain evolution," Brain, Behavior and Evolution 80(3): 167-169.

2012  Miller, D.J., T. Duka, C.D. Stimpson, S.J. Schapiro, W.B. Baze, M.J. McArthur, A.J. Fobbs, A.M. Sousa, N. Sestan, D.E. Wildman, L. Lipovich, C.W. Kuzawa, P.R. Hof, and C.C. Sherwood. "Prolonged myelination in human neocortical evolution," Proceedings of the National Academy of Sciences U S A. 109(41): 16480-16485.

2010  Sherwood, C.C., T. Duka, C.D. Stimpson, N.M. Schenker, A.R. Garrison, S.J. Schapior, W.B. Baze, M.J. McArthur, J.M. Erwin, P.R. Hof, and W.D. Hopkins. "Neocortical synaptophysin asymmetry and behavioral lateralization in chimpanzes (Pan troglodytes)," European Journal of Neuroscience 31(8): 1456-1464.

2009  Duka, T., V. Duka, J.N. Joyce, and A. Sidhu. "alpha-Synuclein contributes to GSK-3 beta-catalized Tau phosphorylation in Parkinson's disease models," FASEB Journal 23(9): 2820-2830. Doi: 10.1096/fj.08-120410.

2006  Duka, T., M. Rusnak, R.E. Drolet, V. Duka, C. Wersinger, J.L. Goudreau, and A. Sidhu. "Alpha-Synuclein induces hyperphosphorylation of Tau in the MPTP model of Parkinsonism," FASEB Journal 20(13): 2302-12. Doi: 10.1096/fj.08-120410.

Classes Taught

Research only.

 

Last updated March 31, 2017